Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types

Hyperactivation of Notch signaling and the cellular hypoxic response are frequently observed in cancers, with increasing reports of connections to tumor initiation and progression. The two signaling mechanisms are known to intersect, but while it is well established that hypoxia regulates Notch sign...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Mutvei, Anders P., Landor, Sebastian K.-J., Fox, Rhys, Braune, Eike-Benjamin, Tsoi, Yat Long, Phoon, Yee Peng, Sahlgren, Cecilia, Hartman, Johan, Bergh, Jonas, Jin, Shaobo, Lendahl, Urban
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237764/
https://ncbi.nlm.nih.gov/pubmed/29993038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0400-3
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