Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

A switch from oxidative phosphorylation to glycolysis is frequently observed in cancer cells and is linked to tumor growth and invasion, but the underpinning molecular mechanisms controlling the switch are poorly understood. In this report we show that Notch signaling is a key regulator of cellular...

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Detalhes bibliográficos
Main Authors: Landor, Sebastian K.-J., Mutvei, Anders P., Mamaeva, Veronika, Jin, Shaobo, Busk, Morten, Borra, Ronald, Grönroos, Tove J., Kronqvist, Pauliina, Lendahl, Urban, Sahlgren, Cecilia Maria
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219154/
https://ncbi.nlm.nih.gov/pubmed/22065781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104943108
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