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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Tumor hypoxia is linked to increased metastatic potential, but the molecular mechanisms coupling hypoxia to metastasis are poorly understood. Here, we show that Notch signaling is required to convert the hypoxic stimulus into epithelial–mesenchymal transition (EMT), increased motility, and invasiven...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Sahlgren, Cecilia, Gustafsson, Maria V., Jin, Shaobo, Poellinger, Lorenz, Lendahl, Urban
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359811/
https://ncbi.nlm.nih.gov/pubmed/18427106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802047105
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