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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Tumor hypoxia is linked to increased metastatic potential, but the molecular mechanisms coupling hypoxia to metastasis are poorly understood. Here, we show that Notch signaling is required to convert the hypoxic stimulus into epithelial–mesenchymal transition (EMT), increased motility, and invasiven...

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Autors principals: Sahlgren, Cecilia, Gustafsson, Maria V., Jin, Shaobo, Poellinger, Lorenz, Lendahl, Urban
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359811/
https://ncbi.nlm.nih.gov/pubmed/18427106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802047105
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