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Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Tumor hypoxia is linked to increased metastatic potential, but the molecular mechanisms coupling hypoxia to metastasis are poorly understood. Here, we show that Notch signaling is required to convert the hypoxic stimulus into epithelial–mesenchymal transition (EMT), increased motility, and invasiven...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2359811/ https://ncbi.nlm.nih.gov/pubmed/18427106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802047105 |
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