Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1α (HIF-1α) becomes stabilized and directly activates transcription of downstream genes. In addition to this “canonical” response, certain aspects of the pathway require integration with Notch signaling, i.e., HIF-1α can i...

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Detalhes bibliográficos
Main Authors: Zheng, Xiaofeng, Linke, Sarah, Dias, José M., Zheng, Xiaowei, Gradin, Katarina, Wallis, Tristan P., Hamilton, Brett R., Gustafsson, Maria, Ruas, Jorge L., Wilkins, Sarah, Bilton, Rebecca L., Brismar, Kerstin, Whitelaw, Murray L., Pereira, Teresa, Gorman, Jeffrey J., Ericson, Johan, Peet, Daniel J., Lendahl, Urban, Poellinger, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265116/
https://ncbi.nlm.nih.gov/pubmed/18299578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711591105
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