Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types

Hyperactivation of Notch signaling and the cellular hypoxic response are frequently observed in cancers, with increasing reports of connections to tumor initiation and progression. The two signaling mechanisms are known to intersect, but while it is well established that hypoxia regulates Notch sign...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncogene
Egile Nagusiak: Mutvei, Anders P., Landor, Sebastian K.-J., Fox, Rhys, Braune, Eike-Benjamin, Tsoi, Yat Long, Phoon, Yee Peng, Sahlgren, Cecilia, Hartman, Johan, Bergh, Jonas, Jin, Shaobo, Lendahl, Urban
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237764/
https://ncbi.nlm.nih.gov/pubmed/29993038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0400-3
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