Antioxidant metabolism regulates CD8(+) T memory stem cell formation and antitumor immunity

Adoptive T cell transfer (ACT) immunotherapy benefits from early differentiated stem cell memory T (Tscm) cells capable of persisting in the long term and generating potent antitumor effectors. Due to their paucity ex vivo, Tscm cells can be derived from naive precursors, but the molecular signals a...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Pilipow, Karolina, Scamardella, Eloise, Puccio, Simone, Gautam, Sanjivan, De Paoli, Federica, Mazza, Emilia M.C., De Simone, Gabriele, Polletti, Sara, Buccilli, Marta, Zanon, Veronica, Di Lucia, Pietro, Iannacone, Matteo, Gattinoni, Luca, Lugli, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237218/
https://ncbi.nlm.nih.gov/pubmed/30232291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122299
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