Antioxidant metabolism regulates CD8(+) T memory stem cell formation and antitumor immunity

Adoptive T cell transfer (ACT) immunotherapy benefits from early differentiated stem cell memory T (Tscm) cells capable of persisting in the long term and generating potent antitumor effectors. Due to their paucity ex vivo, Tscm cells can be derived from naive precursors, but the molecular signals a...

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Vydáno v:JCI Insight
Hlavní autoři: Pilipow, Karolina, Scamardella, Eloise, Puccio, Simone, Gautam, Sanjivan, De Paoli, Federica, Mazza, Emilia M.C., De Simone, Gabriele, Polletti, Sara, Buccilli, Marta, Zanon, Veronica, Di Lucia, Pietro, Iannacone, Matteo, Gattinoni, Luca, Lugli, Enrico
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237218/
https://ncbi.nlm.nih.gov/pubmed/30232291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122299
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