An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules

Covalent modifications of proteins with ubiquitin and ubiquitin-like molecules are instrumental to many biological processes. However, identifying the E3 ligase responsible for these modifications remains a major bottleneck in ubiquitin research. Here, we present an E2-thioester-driven identificatio...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bakos, Gábor, Yu, Lu, Gak, Igor A., Roumeliotis, Theodoros I., Liakopoulos, Dimitris, Choudhary, Jyoti S., Mansfeld, Jörg
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235928/
https://ncbi.nlm.nih.gov/pubmed/30429481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07251-5
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