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Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice

BACKGROUND: Rho-associated kinases (ROCK1 and ROCK2) are important regulators of the actin cytoskeleton and endothelial nitric oxide synthase (eNOS). Because the phosphorylation of eukaryotic elongation factor-1 A1 (eEF1 A1) by ROCK2 is critical for eNOS expression, we hypothesized that this molecul...

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Detalhes bibliográficos
Publicado no:Circ J
Main Authors: Hiroi, Yukio, Noma, Kensuke, Kim, Hyung-Hwan, Sladojevic, Nikola, Tabit, Corey E., Li, Yuxin, Soydan, Guray, Salomone, Salvatore, Moskowitz, Michael A., Liao, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235674/
https://ncbi.nlm.nih.gov/pubmed/29353861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1253/circj.CJ-17-0732
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