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Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening

INTRODUCTION: Pathological cardiac fibrosis, through excessive extracellular matrix protein deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is associated with most forms of cardiovascular disease. Pathological cardiac fibrosis and stiffening can lead to heart fa...

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Vydáno v:Expert Opin Ther Targets
Hlavní autoři: Yu, Brian, Sladojevic, Nikola, Blair, John E., Liao, James K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662835/
https://ncbi.nlm.nih.gov/pubmed/31906742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14728222.2020.1712593
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