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Role of oligouridylation in normal metabolism and regulated degradation of mammalian histone mRNAs

Metazoan replication-dependent histone mRNAs are the only known cellular mRNAs that are not polyadenylated. Histone mRNAs are present in large amounts only in S-phase cells, and their levels are coordinately regulated with the rate of DNA replication. In mammals, the stemloop at the 3′ end of histon...

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Bibliographic Details
Published in:Philos Trans R Soc Lond B Biol Sci
Main Authors: Meaux, Stacie A., Holmquist, Christopher E., Marzluff, William F.
Format: Artigo
Language:Inglês
Published: The Royal Society 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232589/
https://ncbi.nlm.nih.gov/pubmed/30397106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2018.0170
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