Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi

In vertebrate cells, mitochondrial Ca(2+) uptake by the mitochondrial calcium uniporter (MCU) leads to Ca(2+)-mediated stimulation of an intramitochondrial pyruvate dehydrogenase phosphatase (PDP). This enzyme dephosphorylates serine residues in the E1α subunit of pyruvate dehydrogenase (PDH), there...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Lander, Noelia, Chiurillo, Miguel A., Bertolini, Mayara S., Storey, Melissa, Vercesi, Anibal E., Docampo, Roberto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Microbiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231137/
https://ncbi.nlm.nih.gov/pubmed/30232153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004498
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