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Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi
In vertebrate cells, mitochondrial Ca(2+) uptake by the mitochondrial calcium uniporter (MCU) leads to Ca(2+)-mediated stimulation of an intramitochondrial pyruvate dehydrogenase phosphatase (PDP). This enzyme dephosphorylates serine residues in the E1α subunit of pyruvate dehydrogenase (PDH), there...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Biol Chem |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6231137/ https://ncbi.nlm.nih.gov/pubmed/30232153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004498 |
| Tagiau: |
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