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Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi

Pyruvate is the final metabolite of glycolysis and can be converted into acetyl coenzyme A (acetyl-CoA) in mitochondria, where it is used as the substrate for the tricarboxylic acid cycle. Pyruvate availability in mitochondria depends on its active transport through the heterocomplex formed by the m...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Negreiros, Raquel S., Lander, Noelia, Chiurillo, Miguel A., Vercesi, Anibal E., Docampo, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092248/
https://ncbi.nlm.nih.gov/pubmed/33824204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00540-21
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