Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells

The interaction between extrinsic factors and intrinsic signal strength governs thymocyte development, but the mechanisms linking them remain elusive. We report that mTORC1 couples microenvironmental cues with metabolic programs to orchestrate the reciprocal development of two fundamentally distinct...

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Vydáno v:Sci Immunol
Hlavní autoři: Yang, Kai, Bastardo Blanco, Daniel, Chen, Xiang, Dash, Pradyot, Neale, Geoffrey, Rosencrance, Celeste, Easton, John, Chen, Wenan, Cheng, Changde, Dhungana, Yogesh, KC, Anil, Awad, Walid, Guo, Xi-Zhi J., Thomas, Paul G., Chi, Hongbo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230375/
https://ncbi.nlm.nih.gov/pubmed/29980617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aas9818
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