Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells

The interaction between extrinsic factors and intrinsic signal strength governs thymocyte development, but the mechanisms linking them remain elusive. We report that mTORC1 couples microenvironmental cues with metabolic programs to orchestrate the reciprocal development of two fundamentally distinct...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Yang, Kai, Bastardo Blanco, Daniel, Chen, Xiang, Dash, Pradyot, Neale, Geoffrey, Rosencrance, Celeste, Easton, John, Chen, Wenan, Cheng, Changde, Dhungana, Yogesh, KC, Anil, Awad, Walid, Guo, Xi-Zhi J., Thomas, Paul G., Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230375/
https://ncbi.nlm.nih.gov/pubmed/29980617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aas9818
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