Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors

Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited options for treatment. Targeting epigenetic modifications via interfering with the interaction between the bromodomain and extra-terminal domain (BET) proteins and acetylated histones by using BET inhibitors (e.g., JQ1) has sho...

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Udgivet i:Oncotarget
Main Authors: Zhu, Xuguang, Holmsen, Erik, Park, Sunmi, Willingham, Mark C., Qi, Jun, Cheng, Sheue-yann
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226043/
https://ncbi.nlm.nih.gov/pubmed/30459933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26253
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