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Potentiated Anti-tumor Effects of BETi by MEKi in Anaplastic Thyroid Cancer

Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited treatment options. We explored novel treatment modalities by targeting epigenetic modifications using inhibitors of BET (e.g. BRD4) activity. We evaluated the efficacy in the treatment of ATC of a novel BET inhibitor, PLX51107...

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Detalhes bibliográficos
Publicado no:Endocr Relat Cancer
Main Authors: Zhu, Xuguang, Park, Sunmi, Lee, Woo Kyung, Cheng, Sheue-yann
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938575/
https://ncbi.nlm.nih.gov/pubmed/31272080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-19-0107
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