Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer

CONTEXT: Recent studies showed that transcription of the MYC gene is driven by the interaction of bromodomain and extraterminal domain (BET) proteins with acetylated histones on chromatin. JQ1, a potent inhibitor that effectively disrupts the interaction of BET proteins with acetylated histones, pre...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Enomoto, Keisuke, Zhu, Xuguang, Park, Sunmi, Zhao, Li, Zhu, Yuelin J., Willingham, Mark C., Qi, Jun, Copland, John A., Meltzer, Paul, Cheng, Sheue-yann
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Clinical Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505205/
https://ncbi.nlm.nih.gov/pubmed/28368473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2016-3771
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