Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors

Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited options for treatment. Targeting epigenetic modifications via interfering with the interaction between the bromodomain and extra-terminal domain (BET) proteins and acetylated histones by using BET inhibitors (e.g., JQ1) has sho...

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Foilsithe in:Oncotarget
Main Authors: Zhu, Xuguang, Holmsen, Erik, Park, Sunmi, Willingham, Mark C., Qi, Jun, Cheng, Sheue-yann
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2018
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226043/
https://ncbi.nlm.nih.gov/pubmed/30459933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26253
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