Synergistic Signaling of KRAS and Thyroid Hormone Receptor β Mutants Promotes Undifferentiated Thyroid Cancer through MYC Up-Regulation()()

Undifferentiated thyroid carcinoma is one of the most aggressive human cancers with frequent RAS mutations. How mutations of the RAS gene contribute to undifferentiated thyroid cancer remains largely unknown. Mice harboring a potent dominant negative mutant thyroid hormone receptor β, TRβPV (Thrb(PV...

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Vydáno v:Neoplasia
Hlavní autoři: Zhu, Xuguang, Zhao, Li, Park, Jeong Won, Willingham, Mark C., Cheng, Sheue-yann
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234871/
https://ncbi.nlm.nih.gov/pubmed/25246276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.08.003
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