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Synergistic Signaling of KRAS and Thyroid Hormone Receptor β Mutants Promotes Undifferentiated Thyroid Cancer through MYC Up-Regulation()()

Undifferentiated thyroid carcinoma is one of the most aggressive human cancers with frequent RAS mutations. How mutations of the RAS gene contribute to undifferentiated thyroid cancer remains largely unknown. Mice harboring a potent dominant negative mutant thyroid hormone receptor β, TRβPV (Thrb(PV...

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Publié dans:Neoplasia
Auteurs principaux: Zhu, Xuguang, Zhao, Li, Park, Jeong Won, Willingham, Mark C., Cheng, Sheue-yann
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234871/
https://ncbi.nlm.nih.gov/pubmed/25246276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.08.003
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