RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

Wnt/β-catenin signaling mediates cancer immune evasion and resistance to immune checkpoint therapy, in part by blocking cytokines that trigger immune cell recruitment. Inhibition of β-catenin may be an effective strategy for increasing the low response rate to these effective medicines in numerous c...

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Publicat a:Mol Ther
Autors principals: Ganesh, Shanthi, Shui, Xue, Craig, Kevin P., Park, Jihye, Wang, Weimin, Brown, Bob D., Abrams, Marc T.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225018/
https://ncbi.nlm.nih.gov/pubmed/30274786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.09.005
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