Direct pharmacological inhibition of β-catenin by RNA interference in tumors of diverse origin

The Wnt/β-catenin pathway is among the most frequently altered signaling networks in human cancers. Despite decades of preclinical and clinical research, efficient therapeutic targeting of Wnt/β-catenin has been elusive. RNA interference (RNAi) technology silences genes at the mRNA level, and theref...

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Pubblicato in:Mol Cancer Ther
Autori principali: Ganesh, Shanthi, Koser, Martin, Cyr, Wendy, Chopda, Girish, Tao, Junyan, Shui, Xue, Ying, Bo, Chen, Dongyu, Pandya, Purva, Chipumuro, Edmond, Siddiquee, Zakir, Craig, Kevin, Lai, Chengjung, Dudek, Henryk, Monga, Satdarshan, Wang, Weimin, Brown, Bob D., Abrams, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010976/
https://ncbi.nlm.nih.gov/pubmed/27390343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0309
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