Src-transformed cells hijack mitosis to extrude from the epithelium

At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic...

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Bibliographic Details
Published in:	Nat Commun
Main Authors:	Anton, Katarzyna A., Kajita, Mihoko, Narumi, Rika, Fujita, Yasuyuki, Tada, Masazumi
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group UK 2018
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6224566/ https://ncbi.nlm.nih.gov/pubmed/30410020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07163-4
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Src-transformed cells hijack mitosis to extrude from the epithelium

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