Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association

BACKGROUND: Large cancer genome studies continue to reveal new players in treatment response and tumorigenesis. The discrimination of functional alterations from the abundance of passenger genetic alterations still poses challenges and determines DNA sequence variant selection procedures. Here we ev...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vossen, David M., Verhagen, Caroline V. M., Grénman, Reidar, Kluin, Roelof J. C., Verheij, Marcel, van den Brekel, Michiel W. M., Wessels, Lodewyk F. A., Vens, Conchita
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224072/
https://ncbi.nlm.nih.gov/pubmed/30408064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206632
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