Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association

BACKGROUND: Large cancer genome studies continue to reveal new players in treatment response and tumorigenesis. The discrimination of functional alterations from the abundance of passenger genetic alterations still poses challenges and determines DNA sequence variant selection procedures. Here we ev...

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Publicat a:PLoS One
Autors principals: Vossen, David M., Verhagen, Caroline V. M., Grénman, Reidar, Kluin, Roelof J. C., Verheij, Marcel, van den Brekel, Michiel W. M., Wessels, Lodewyk F. A., Vens, Conchita
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224072/
https://ncbi.nlm.nih.gov/pubmed/30408064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206632
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