Biological Determinants of Chemo-Radiotherapy Response in HPV-Negative Head and Neck Cancer: A Multicentric External Validation

Purpose: Tumor markers that are related to hypoxia, proliferation, DNA damage repair and stem cell-ness, have a prognostic value in advanced stage HNSCC patients when assessed individually. Here we aimed to evaluate and validate this in a multifactorial context and assess interrelation and the combi...

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Main Authors: Martijn van der Heijden, Paul B. M. Essers, Monique C. de Jong, Reinout H. de Roest, Sebastian Sanduleanu, Caroline V. M. Verhagen, Olga Hamming-Vrieze, Frank Hoebers, Philippe Lambin, Harry Bartelink, C. René Leemans, Marcel Verheij, Ruud H. Brakenhoff, Michiel W. M. van den Brekel, Conchita Vens
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-01-01
Colecção:Frontiers in Oncology
Assuntos:
HNSCC
chemoradiotherapy
radiation resistance
hypoxia
immune cell infiltration
expression profile analysis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2019.01470/full
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