Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma

Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and patient outcome. Their functional impact and clinical relevance in head and neck squamous cell carcinoma (HNSCC) is unknown. We therefore questi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Verhagen, Caroline V.M., Vossen, David M., Borgmann, Kerstin, Hageman, Floor, Grénman, Reidar, Verwijs-Janssen, Manon, Mout, Lisanne, Kluin, Roel J.C., Nieuwland, Marja, Severson, Tesa M., Velds, Arno, Kerkhoven, Ron, O’Connor, Mark J., van der Heijden, Martijn, van Velthuysen, Marie-Louise, Verheij, Marcel, Wreesmann, Volkert B., Wessels, Lodewyk F.A., van den Brekel, Michiel W.M., Vens, Conchita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915066/
https://ncbi.nlm.nih.gov/pubmed/29719599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24797
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi