Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma

Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and patient outcome. Their functional impact and clinical relevance in head and neck squamous cell carcinoma (HNSCC) is unknown. We therefore questi...

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Vydáno v:Oncotarget
Hlavní autoři: Verhagen, Caroline V.M., Vossen, David M., Borgmann, Kerstin, Hageman, Floor, Grénman, Reidar, Verwijs-Janssen, Manon, Mout, Lisanne, Kluin, Roel J.C., Nieuwland, Marja, Severson, Tesa M., Velds, Arno, Kerkhoven, Ron, O’Connor, Mark J., van der Heijden, Martijn, van Velthuysen, Marie-Louise, Verheij, Marcel, Wreesmann, Volkert B., Wessels, Lodewyk F.A., van den Brekel, Michiel W.M., Vens, Conchita
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915066/
https://ncbi.nlm.nih.gov/pubmed/29719599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24797
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