Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms

Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1‐like’ or ‘non‐BRCA1‐like’, which refers to resembling a BRCA1‐mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approxim...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Schouten, Philip C., Grigoriadis, Anita, Kuilman, Thomas, Mirza, Hasan, Watkins, Johnathan A., Cooke, Saskia A., van Dyk, Ewald, Severson, Tesa M., Rueda, Oscar M., Hoogstraat, Marlous, Verhagen, Caroline V.M., Natrajan, Rachael, Chin, Suet-Feung, Lips, Esther H., Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Krijgsman, Oscar, Vens, Conchita, Peeper, Daniel, Nederlof, Petra M., Caldas, Carlos, Tutt, Andrew N., Wessels, Lodewyk F., Linn, Sabine C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528812/
https://ncbi.nlm.nih.gov/pubmed/25825120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.03.002
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