Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms

Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1‐like’ or ‘non‐BRCA1‐like’, which refers to resembling a BRCA1‐mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approxim...

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Vydáno v:Mol Oncol
Hlavní autoři: Schouten, Philip C., Grigoriadis, Anita, Kuilman, Thomas, Mirza, Hasan, Watkins, Johnathan A., Cooke, Saskia A., van Dyk, Ewald, Severson, Tesa M., Rueda, Oscar M., Hoogstraat, Marlous, Verhagen, Caroline V.M., Natrajan, Rachael, Chin, Suet-Feung, Lips, Esther H., Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Krijgsman, Oscar, Vens, Conchita, Peeper, Daniel, Nederlof, Petra M., Caldas, Carlos, Tutt, Andrew N., Wessels, Lodewyk F., Linn, Sabine C.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528812/
https://ncbi.nlm.nih.gov/pubmed/25825120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.03.002
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