A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1–Dna2 in long-range DNA end resection

The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is initiated by nucleolytic resection of the DNA break ends. The current model, being based primarily on genetic analyses in Saccharomyces cerevisiae and companion biochemical reconstitution studies, posits that end resec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Weibin, Daley, James M., Kwon, Youngho, Xue, Xiaoyu, Krasner, Danielle S., Miller, Adam S., Nguyen, Kevin A., Williamson, Elizabeth A., Shim, Eun Yong, Lee, Sang Eun, Hromas, Robert, Sung, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222114/
https://ncbi.nlm.nih.gov/pubmed/30224356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004769
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