InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis

The enoyl-thioester reductase InhA catalyzes an essential step in fatty acid biosynthesis of Mycobacterium tuberculosis and is a key target of antituberculosis drugs to combat multidrug-resistant M. tuberculosis strains. This has prompted intense interest in the mechanism and intermediates of the In...

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Foilsithe in:J Biol Chem
Main Authors: Vögeli, Bastian, Rosenthal, Raoul G., Stoffel, Gabriele M. M., Wagner, Tristan, Kiefer, Patrick, Cortina, Niña Socorro, Shima, Seigo, Erb, Tobias J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Enzymology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222099/
https://ncbi.nlm.nih.gov/pubmed/30217823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005405
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