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A conserved threonine prevents self-intoxication of enoyl-thioester reductases
Enzymes are highly specific biocatalysts, yet they can perform unwanted side reactions. Here we investigated the factors that direct catalysis in the enoyl-thioester reductase Etr1p. We show that a single conserved threonine is essential in suppressing the formation of a side product that otherwise...
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| Vydáno v: | Nat Chem Biol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5892710/ https://ncbi.nlm.nih.gov/pubmed/28504678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2375 |
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