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A conserved threonine prevents self-intoxication of enoyl-thioester reductases

Enzymes are highly specific biocatalysts, yet they can perform unwanted side reactions. Here we investigated the factors that direct catalysis in the enoyl-thioester reductase Etr1p. We show that a single conserved threonine is essential in suppressing the formation of a side product that otherwise...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Rosenthal, Raoul G., Vögeli, Bastian, Wagner, Tristan, Shima, Seigo, Erb, Tobias J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892710/
https://ncbi.nlm.nih.gov/pubmed/28504678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2375
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