Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site

Many reactions within a cell are thermodynamically unfavorable. To efficiently run some of those endergonic reactions, nature evolved intermediate-channeling enzyme complexes, in which the products of the first endergonic reactions are immediately consumed by the second exergonic reactions. Based on...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Vögeli, Bastian, Engilberge, Sylvain, Girard, Eric, Riobé, François, Maury, Olivier, Erb, Tobias J., Shima, Seigo, Wagner, Tristan
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879682/
https://ncbi.nlm.nih.gov/pubmed/29531083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718649115
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