The multi-catalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite

Cells need to cope with toxic or reactive intermediates formed during metabolism. One strategy is to sequester reactions that produce such intermediates within specialized compartments or tunnels connecting different active sites. Here we show that propionyl-CoA synthase (PCS), a ~400 kDa homodimer,...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Bernhardsgrütter, Iria, Vögeli, Bastian, Wagner, Tristan, Peter, Dominik M., Cortina, Niña Socorro, Bange, Gert, Engilberge, Sylvain, Girard, Eric, Riobé, François, Maury, Olivier, Shima, Seigo, Zarzycki, Jan, Erb, Tobias J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499725/
https://ncbi.nlm.nih.gov/pubmed/30374166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0153-x
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