A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters

Coenzyme A (CoA) is a ubiquitous cofactor present in every known organism. The thioesters of CoA are core intermediates in many metabolic processes, such as the citric acid cycle, fatty acid biosynthesis and secondary metabolism, including polyketide biosynthesis. Synthesis of CoA-thioesters is vita...

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Detalhes bibliográficos
Main Authors: Dominik M. Peter, Bastian Vögeli, Niña Socorro Cortina, Tobias J. Erb
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2016-04-01
Colecção:Molecules
Assuntos:
CoA-thioester
acylation
acyl-CoA dehydrogenases
enzyme promiscuity
secondary metabolites
polyketide synthase
natural product biosynthesis
biocatalysis
extender units
Acesso em linha:http://www.mdpi.com/1420-3049/21/4/517
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