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The multi-catalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite
Cells need to cope with toxic or reactive intermediates formed during metabolism. One strategy is to sequester reactions that produce such intermediates within specialized compartments or tunnels connecting different active sites. Here we show that propionyl-CoA synthase (PCS), a ~400 kDa homodimer,...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Chem Biol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6499725/ https://ncbi.nlm.nih.gov/pubmed/30374166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0153-x |
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