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Superior protein titers in half the fermentation time: Promoter and process engineering for the glucose‐regulated GTH1 promoter of Pichia pastoris
Protein production in Pichia pastoris is often based on the methanol‐inducible P (AOX1) promoter which drives the expression of the target gene. The use of methanol has major drawbacks, so there is a demand for alternative promoters with good induction properties such as the glucose‐regulated P (GTH...
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| Pubblicato in: | Biotechnol Bioeng |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6221138/ https://ncbi.nlm.nih.gov/pubmed/30016537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26800 |
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