Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS

[Image: see text] Top-down proteomics is an emerging analytical strategy to characterize combinatorial protein post-translational modifications (PTMs). However, sample complexity and small mass differences between chemically closely related proteoforms often limit the resolution attainable by separa...

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Publicat a:J Proteome Res
Autors principals: Gargano, Andrea F. G., Shaw, Jared B., Zhou, Mowei, Wilkins, Christopher S., Fillmore, Thomas L., Moore, Ronald J., Somsen, Govert W., Paša-Tolić, Ljiljana
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220366/
https://ncbi.nlm.nih.gov/pubmed/30226781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.8b00458
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