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Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins

Trifluoroacetic acid (TFA) is commonly used as mobile phase additive to improve retention and peak shape characteristics in hydrophilic interaction liquid chromatography (HILIC) of intact proteins. However, when using electrospray ionization-mass spectrometry (ESI-MS) detection, TFA may cause ioniza...

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Bibliografiska uppgifter
I publikationen:Anal Bioanal Chem
Huvudupphovsmän: Wouters, Sam, Eeltink, Sebastiaan, Haselberg, Rob, Somsen, Govert W., Gargano, Andrea F. G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245364/
https://ncbi.nlm.nih.gov/pubmed/34050389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-021-03414-4
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