Sirtuin1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel

The voltage-gated cardiac Na+ channel (Nav1.5), encoded by the SCN5A gene, conducts the inward depolarizing cardiac Na+ current (I(Na)) and is vital for normal cardiac electrical activity. Inherited loss-of-function mutations in SCN5A lead to defects in the generation and conduction of the cardiac e...

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Publicado no:Nat Med
Main Authors: Vikram, Ajit, Lewarchik, Christopher M, Yoon, Jin-Young, Naqvi, Asma, Kumar, Santosh, Morgan, Gina M, Jacobs, Julia S, Li, Qiuxia, Kim, Young-Rae, Kassan, Modar, Liu, Jing, Gabani, Mohanad, Kumar, Ajay, Mehdi, Haider, Zhu, Xiaodong, Guan, Xiaoqun, Kutschke, William, Zhang, Xiaoming, Boudreau, Ryan L, Dai, Shengchuan, Matasic, Daniel S, Jung, Saet-Byel, Margulies, Kenneth B, Kumar, Vikas, Bachschmid, Markus M, London, Barry, Irani, Kaikobad
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218171/
https://ncbi.nlm.nih.gov/pubmed/28191886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4284
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