Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation

Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [(18)F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mouse models. Therefore, we applied this thera...

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Detalles Bibliográficos
Publicado en:Theranostics
Main Authors: Brendel, Matthias, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Probst, Federico, Gildehaus, Franz-Josef, Bartenstein, Peter, Haass, Christian, Bohrmann, Bernd, Herms, Jochen, Willem, Michael, Rominger, Axel
Formato: Artigo
Idioma:Inglês
Publicado: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217065/
https://ncbi.nlm.nih.gov/pubmed/30429879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.27868
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