Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation

Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [(18)F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mouse models. Therefore, we applied this thera...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Theranostics
Päätekijät: Brendel, Matthias, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Probst, Federico, Gildehaus, Franz-Josef, Bartenstein, Peter, Haass, Christian, Bohrmann, Bernd, Herms, Jochen, Willem, Michael, Rominger, Axel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Ivyspring International Publisher 2018
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217065/
https://ncbi.nlm.nih.gov/pubmed/30429879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.27868
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