Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation

Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [(18)F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mouse models. Therefore, we applied this thera...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Brendel, Matthias, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Probst, Federico, Gildehaus, Franz-Josef, Bartenstein, Peter, Haass, Christian, Bohrmann, Bernd, Herms, Jochen, Willem, Michael, Rominger, Axel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217065/
https://ncbi.nlm.nih.gov/pubmed/30429879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.27868
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge