Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation

Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [(18)F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mouse models. Therefore, we applied this thera...

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Dettagli Bibliografici
Pubblicato in:Theranostics
Autori principali: Brendel, Matthias, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Probst, Federico, Gildehaus, Franz-Josef, Bartenstein, Peter, Haass, Christian, Bohrmann, Bernd, Herms, Jochen, Willem, Michael, Rominger, Axel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217065/
https://ncbi.nlm.nih.gov/pubmed/30429879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.27868
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