DDIS-13. UNDERSTANDING GLIOBLASTOMA SUSCEPTIBILITY TO TOP2-TARGETING DRUGS FOR PERSONALIZED THERAPY

Poor outcomes in glioblastoma are partially explained by unpredictable individual responses to therapy. Topoisomerase II (TOP2) poisons Etoposide and Doxorubicin, which induce double-strand DNA breaks, are effective for some glioblastoma lines. On the other hand, the TOP2-enzymatic inhibitor MST16 i...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Awah, Chidiebere, Gonzalez-Buendía, Edgar, Zhao, Junfei, Feldstein, Eric, Chen, Li, Mahajan, Aayushi, Warnke, Louisa, Wang, Lu, Park, Cheol, Winter, Jan, Konermann, Silvana, Shilatifard, Ali, James, C David, Rabadan, Raul, Hsu, Patrick, Bansal, Mukesh, Ahmed, Atique, Sonabend, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216601/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.292
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