PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates

Clinical applications of camptothecin (CPT) have been heavily hindered due to its non-targeted toxicity, active lactone ring instability, and poor water solubility. Targeted drug delivery systems may offer the possibility to overcome the above issues as reported. In this research, a series of prosta...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Xu, Bing, Zhou, Fei, Yan, Meng-Meng, Cai, De-Sheng, Guo, Wen-Bo, Yang, Yu-Qin, Jia, Xiao-Hui, Zhang, Wen-Xi, Li, Tong, Ma, Tao, Wang, Peng-Long, Lei, Hai-Min
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214026/
https://ncbi.nlm.nih.gov/pubmed/30347770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103251
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