Sustained delivery of a camptothecin prodrug – CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity

Background and aim: We have synthesized a novel lactone-stabilized camptothecin (CPT) analog named CZ48 and demonstrated its potent anticancer effects via bioconversion to the active CPT in earlier studies. Herein, we aimed to develop, optimize and characterize CZ48 nanosuspensions, for a sustained...

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Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Dong, Dong, Hsiao, Cheng-Hui, Giovanella, Beppino C, Wang, Yifei, Chow, Diana SL, Li, Zhijie
Format: Artigo
Language:Inglês
Published: Dove 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540077/
https://ncbi.nlm.nih.gov/pubmed/31213802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S196453
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