Functional redundancy between RAP1 isoforms in murine platelet production and function

RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a normal platelet count, suggesting the existence of a...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Stefanini, Lucia, Lee, Robert H., Paul, David S., O'Shaughnessy, Ellen C., Ghalloussi, Dorsaf, Jones, Christopher I., Boulaftali, Yacine, Poe, Kathryn O., Piatt, Raymond, Kechele, Dan O., Caron, Kathleen M., Hahn, Klaus M., Gibbins, Jonathan M., Bergmeier, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213319/
https://ncbi.nlm.nih.gov/pubmed/30131434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838714
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