RASA3 is a critical inhibitor of RAP1-dependent platelet activation

The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an unknown regulator that operates downstream of the adenosine diphosphate (ADP) receptor, P2Y12, a target of antithrombotic therapy. Here, we provide...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Stefanini, Lucia, Paul, David S., Robledo, Raymond F., Chan, E. Ricky, Getz, Todd M., Campbell, Robert A., Kechele, Daniel O., Casari, Caterina, Piatt, Raymond, Caron, Kathleen M., Mackman, Nigel, Weyrich, Andrew S., Parrott, Matthew C., Boulaftali, Yacine, Adams, Mark D., Peters, Luanne L., Bergmeier, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396462/
https://ncbi.nlm.nih.gov/pubmed/25705885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77993
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