RASA3 is a critical inhibitor of RAP1-dependent platelet activation

The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an unknown regulator that operates downstream of the adenosine diphosphate (ADP) receptor, P2Y12, a target of antithrombotic therapy. Here, we provide...

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Vydáno v:J Clin Invest
Hlavní autoři: Stefanini, Lucia, Paul, David S., Robledo, Raymond F., Chan, E. Ricky, Getz, Todd M., Campbell, Robert A., Kechele, Daniel O., Casari, Caterina, Piatt, Raymond, Caron, Kathleen M., Mackman, Nigel, Weyrich, Andrew S., Parrott, Matthew C., Boulaftali, Yacine, Adams, Mark D., Peters, Luanne L., Bergmeier, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396462/
https://ncbi.nlm.nih.gov/pubmed/25705885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77993
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