Functional redundancy between RAP1 isoforms in murine platelet production and function

RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a normal platelet count, suggesting the existence of a...

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Publicado en:Blood
Autores principales: Stefanini, Lucia, Lee, Robert H., Paul, David S., O'Shaughnessy, Ellen C., Ghalloussi, Dorsaf, Jones, Christopher I., Boulaftali, Yacine, Poe, Kathryn O., Piatt, Raymond, Kechele, Dan O., Caron, Kathleen M., Hahn, Klaus M., Gibbins, Jonathan M., Bergmeier, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2018
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213319/
https://ncbi.nlm.nih.gov/pubmed/30131434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838714
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